Arterial dissections have been well recognized at the cervical portion of the internal carotid artery and extracranial vertebral artery as an important cause of stroke, especially in young and middle-aged patients and accounting for 10 to 25 percent of such cases.8) They are usually a consequence of
trauma or spontaneous. Collagen vascular disease may play an important role in the pathogenesis of spontaneous arterial dissection, particularly when multiple vessels are involved.1)
Multiple dissections should therefore prompt thorough investigation including potential risk factors, family history, and pathologic examination of skin connective tissue to assess for primary arterial disease. We describe a patient who presented with neurologic symptoms consistent with a stroke and found to have dissecting aneurysms of carotid and basilar arteries following minor craniocervical trauma without known underlying collagen vascular disease. The mechanism and treatment of the dissections are discussed.
Case Report
A 21-year-old man driving a car was involved in a headon collision with a truck. He was wearing a three-point retractable shoulder harness seat belt. He had a transient loss of consciousness just after the crash. On admission, neurological findings showed an oriented patient with severe left-sided hemiparesis and dysarthria. Babinski’'s sign was present on the left side. There was ecchymosis over the course of the safety belt. The past medical history was unremarkable. On examination he was hemodynamically
stable and laboratory findings were normal. Electrocardiogram and radiograms of chest, skull and
cervical spine showed normal findings. T1-weighted MRI showed mass with high signal intensity
rim and internal isosignal intensity in the prepontine cistern, which was suggestive of thrombosed vascular lumen of basilar artery (Fig. 1A). T2-weighted MRI revealed highsignal change in dorsal pons and upper medulla, and the anterior inferior cerebellar artery (AICA) territory of cerebellum, suggestive of recent infarction, and mass effect on the brain stem was prominent. T1-weighted gadoliniumenhanced
MRI showed a distinct enhancement at the same region of the BA occlusion. There is no signal change on supratentorial brain parenchyma. MR angiography showed bulbously dilated proximal half of BA and severely narrowed mid-BA (Fig. 1B). Cerebral angiograms showed complete occlusion at just distal to the confluence site (Fig. 2A), and irregularly fusiform aneurysmal dilatation of cervical portion of the left ICA, consistent with dissection (Fig. 2B). A carotid angiogram showed retrograde contrast filling into the distal half of the BA with preserved patency of posterior cerebral arteries and superior cerebellar arteries
(Fig. 2C). Therefore, BA dissection was treated conservatively with antiplatelet medications and ICA
dissection was planned for stent placement. On day 7, stents deployment for left ICA dissection was
successfully achieved. First stent (Precise, Cordis Co, 6mm × 40mm) was introduced into the dissecting aneurysm. After stent placement, angiography showed persistent filling of aneurysm, but the speed of contrast filling was delayed. Then second stent (Precise, Cordis Co, 6mm × 40mm) was deployed in overlapping fashion. The final carotid angiograms showed minimal contrast filling of aneurysm
(Fig. 2D). The postoperative course was uneventful. On day 11, the patient was discharged with antiplatelet medications and transferred to military hospital for rehabilitation. At a 17-month follow-up examination, left-sided hemiparesis was much improved but mild dysarthria still remained, but MRI showed further shrinkage of the BA dissecting aneurysm without evidence of recanalization of
the occluded BA (Fig. 3A). Vertebral angiograms showed no recanalization of the occluded BA and left carotid angiograms revealed well-restored luminal configuration of left ICA without contrast filling of aneurysm (Fig. 3B).
Discussion
Arterial dissection typically occurs in young adults, with an annual incidence of 2.6 per 100,000.3,9) It is usually a consequence of trauma, either major trauma such as car accident with whiplash injury or more frequently, minor or even ‘rivial’ A concomitant traumatic factor in the
pathogenesis of dissection is possible through internal mechanical forces exerted on the neck or head by unusual positions or rapid head turning. For example, a wide spectrum of sport and fitness activities, chiropractic manipulation, violent coughing or nose-blowing can precede arterial dissection. In our case, a sustained hyperflexion status might give rise to arterial dissection. In multiple dissections, even in the setting of known minor trauma, an underlying collagen vascular disease should be suspected. ICA dissection has been associated with heritable connective tissue disorders such as Ehlers-Danlos syndrome
type IV and Marfan’ syndrome, suggesting that a defect in a single extracellular matrix component may be responsible for a more fragile vessel wall which under certain conditions could give rise to a dissection.7,9) Because of frequent mild phenotype expression, the primary underlying heritable
connective tissue disorder is often diagnosed only after the occurrence of dissection.5)
Our patient’ sudden neurological deterioration was associated with brain stem infarction caused by BA and its branch occlusions secondary to BA dissection. Definitive diagnosis depends mainly on demonstration of intramural hematoma.2) MRI can directly demonstrate an intramural hematoma, the signal intensity of which varies with the age of the hematoma. MRI and angiography are modalities that
complement each other, and thus we consider both to be necessary for accurate diagnosis.
Although the ICA dissecting aneurysm was asymptomatic, stents implantation was achieved to prevent extension of dissection and thromboembolic complications. BA occlusion due to BA dissection initially was characterized by a severe neurological impairment. A therapeutic strategy for unruptured BA dissection has not been established, however, anticoagulation therapy for intracranial dissecting aneurysm has not been widely advocated because it may aggravate the risk of rupture.4) Sequential radiological studies revealing neither subsequent ischemic insult nor aneurysmal dilatation justified conservative treatment for BA dissection as previous reports, which revealed spontaneous healing of the BA dissections in case of unruptured BA dissection.6) The indications of treatment for ischemic BA dissections would be limited to the following two situations : 1) A persistent pseudolumen indicating a risk of future ischemic insults and
2) aneurysmal growth occurring as a sequela of dissection indicating a risk of future hemorrhage. In our patient, neither subsequent ischemic insult nor aneurysmal dilatation was observed during the 17-month follow-up period. Therefore, non-surgical treatment appeared to be justified. Furthermore, a rich collateral circulation developed, and spontaneous healing of the dissected pseudolumen was demonstrated.
REFERENCES
11) Eachempati SR, Sebastian MW, Reed RL, 2nd: Posttraumatic bilateral carotid artery and right vertebral artery dissections
in a patient with fibromuscular dysplasia: case report and review of the literature. J Trauma 44:406-9, 1998
12) Kitanaka C, Tanaka J, Kuwahara M, Teraoka A: Magnetic resonance imaging study of intracranial vertebrobasilar artery
dissections. Stroke 25:571-5, 1994
13) Leys D, Lucas C, Gobert M, Deklunder G, Pruvo JP: Cervical artery dissections. Eur Neurol 37:3-12, 1997
14) Maeda K, Usui M, Tsutsumi K, Iijima A: Spontaneous occlusion of a giant basilar tip aneurysm and a basilar artery
due to the dissection of both structures: case report. Surg Neurol 48:606-9, 1997
15) Mayer SA, Rubin BS, Starman BJ, Byers PH: Spontaneous multivessel cervical artery dissection in a patient with a
substitution of alanine for glycine (G13A) in the alpha 1 (I) chain of type I collagen. Neurology 47:552-6, 1996
16) Nakatomi H, Nagata K, Kawamoto S, Furusho JI: Basilar artery occlusion due to spontaneous basilar artery dissection
in a child. Acta Neurochir (Wien) 141:99-104, 1999
17) North KN, Whiteman DA, Pepin MG, Byers PH: Cerebrovascular complications in Ehlers-Danlos syndrome type IV. Ann Neurol 38:960-4, 1995
18) Schievink WI: Spontaneous dissection of the carotid and vertebral arteries. N Engl J Med 344:898-906, 2001
19) Schievink WI, Bjornsson J, Piepgras DG: Coexistence of fibromuscular dysplasia and cystic medial necrosis in a patient
with Marfan’ syndrome and bilateral carotid artery dissections. Stroke 25:2492-6, 1994